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A comment on Cocaine Paraphernalia Ads in the 70s. Parent comment

Re:Cocaine Paraphernalia Ads in the 70s by kortex on Tuesday November 23, 2021 @10:48AM (#29319176)
Cocaine also induces microischemia - basically constricts your capillaries and starves the neurons/glia of oxygen. This happens slowly over time and is cumulative.

As mentioned, coke is high on the abuse potential scale due to its rapid onset and withdrawal, short loop between behavior and reward.

https://www.pbs.org/newshour/science/brains-blood-cocaine

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Re:Cocaine Paraphernalia Ads in the 70s by runnerup on Tuesday November 23, 2021 @05:15PM (#29324251)
Alcohol also causes ischemia. Prescription amphetamines also cause ischemia but are legal.

> As mentioned, coke is high on the abuse potential scale due to its rapid onset and withdrawal, short loop between behavior and reward.

I wonder if attaching an amino acid (a la Vyvanse) would improve its pharmacokinetic profile to reduce this addiction potential. We'll never know, because its not legal to do research on medical potential for Schedule I drugs.

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Re:Cocaine Paraphernalia Ads in the 70s by ycombinete on Tuesday November 23, 2021 @11:33AM (#29319804)
Not to mention that people are highly functional while high on it. So there’s no downtime on when you can be high.
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