https://youtu.be/Xu1FMCxoEFc?t=5928

99:33 But one of the things that came up

99:35 and is a fundamental question that I had,

99:37 that I think probably many of you are asking,

99:38 is does the experience that one has on these compounds

99:43 make a difference for whether or not somebody gains relief

99:46 from depression, from these psilocybin journeys or not?

99:50 In other words, does it matter what they talk about?

99:52 Does it matter what they think about?

99:53 Does it matter if they have a good trip or a bad trip?

99:56 And I don't want to hold you in too much suspense,

99:58 I'll let Matthew provide the more thorough answer.

100:00 But what's really interesting

100:02 is there are some common themes to psilocybin administration

100:08 and experience that lead to relief from depressive symptoms,

100:11 but they are subjectively very varied,

100:17 meaning that whether or not people feel

100:20 they had a good experience or a bad experience,

100:22 whether or not people thought about their parents

100:24 or thought about the color of the ceiling,

100:27 doesn't seem to have too much of an impact

100:30 on whether or not they receive relief

100:32 during these studies in these clinical studies.

100:37 It seems like different people can have

100:38 lots of different experiences and still receive benefit.

100:42 And that points to something deeper.

100:45 It points to the fact that these drugs,

100:48 which is really what they are,

100:49 are rewiring neural circuitry in a common way

100:53 despite a diversity of experience while on the drug.

100:57 And that itself is really interesting.

100:58 And it takes us back to a place that we've been before

101:01 in this discussion, which is layer five of the cortex.

101:04 This area that ketamine seems to impact as well

101:06 by generating rhythms of the,

101:08 I mentioned one to three Hertz activity

101:10 in layer five of certain areas of the cortex.