If you're asking this here, I'd say don't do it. Don't presume you have to go for it, especially right now. Keep in mind she may take on about as much of the risks and downside as you do without the personal satisfaction you get out of it.

Colin Powell may not be President of the US right now simply because his wife is not up for it it. But even though he could push her into battle or steamroll her, he doesn't. Just shows that he's a smart guy and model husband -- two traits not often combined in presidents, as it so happens.