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A comment on Organ transplant patients may not get dementia. Parent comment

Re:Organ transplant patients may not get dementia by renewiltord on Wednesday November 03, 2021 @01:11PM (#29097498)
Sorry, haven’t read these yet, but any antibodies? Like any immune response makes you duller and at greater risk? Eek.
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Re:Organ transplant patients may not get dementia by burning_hamster on Wednesday November 03, 2021 @01:35PM (#29097843)
Like I said, I can't find the study right now, and I originally saw the data anywhere between 5-10 years ago. They may also have been measuring some cytokine. Even without AD, memories really aren't reliable over that time span.

The point the authors were trying to make is that if you have AD, any inflammation, even asymptomatic ones, will potentially worsen your cognitive performance. The most interesting feature of that graph was to me that the cognitive performance actually remained fairly constant in between infections/inflammations, and decline was not gradual but in a step-wise fashion.

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Re:Organ transplant patients may not get dementia by axutio on Wednesday November 03, 2021 @02:10PM (#29098333)
Also interesting is ISRIB [0,1], which is intended to negate the cognitive impacts of stress memory accumulated over years of immune response, and possibly as a result of TBI as well [2].

[0] https://en.wikipedia.org/wiki/ISRIB

[1] https://doi.org/10.1073/pnas.1815767116

[2] https://doi.org/10.1073/pnas.1707661114

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