Hughes was a direct part of Watergate.
Still, to this day, there is no amazing treatment for it. Especially because there are more than a few not well understood causes of it. Some medications work well for some, but not at all for others.
Hughes was, by all accounts, essentially a prisoner of his unrelenting misfiring nervous system. I think he lived out his final years with it in a fairly reasonable way.
Speaking as somebody with a moderate case of allodynia caused by a functional musculoskeletal condition, if my case was a bit worse, with no hope for treatment in sight, and I was loaded like he was - I too would likely spend my time in isolation and on a lot of drugs, really anything that would relieve the sensory pain, no matter how cognitively impaired it may make me.
allodynia: “Allodynia is a type of neuropathic pain (nerve pain). People with allodynia are extremely sensitive to touch. Things that don't usually cause pain can be very painful. These may include cold temperatures, brushing hair or wearing a cotton t-shirt. Allodynia can result from several conditions.”
https://my.clevelandclinic.org/health/symptoms/21570-allodyn...
https://www.latimes.com/visuals/photography/la-me-fw-archive...