It's clearly very hard for folks who have come to rely upon their workplace as their venue for social interaction, and their co-worker pool as their source for social relationships. But to be clear, once upon a time (back in the long long ago), it was seen as unhealthy to mix your work relationships and your personal friendships. So it's possible for all of us to learn how to develop relationships and friendships that don't rely upon the forced proximity of an office. Things like shared activities, social organizations, etc are a good starting point.