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A comment on Canada's 'gamble' on delaying, mixing and matching Covid-19 vaccines paid off. Parent comment

Re:Canada's 'gamble' on delaying, mixing and matching Covid-... by Causality1 on Sunday October 10, 2021 @02:37AM (#28816287)
Why is it luck? They all result in exposing the body to the exact same spike protein. We would have to be dangerously wrong about what the vaccines do for them to not work fine together.
[ Parent | on HN ]
Re:Canada's 'gamble' on delaying, mixing and matching Covid-... by refurb on Sunday October 10, 2021 @03:03AM (#28816402)
It’s not the exact same spike protein.
[ Parent | on HN ]
Re:Canada's 'gamble' on delaying, mixing and matching Covid-... by Causality1 on Sunday October 10, 2021 @10:00AM (#28818475)
The differences are stabilizers intended to prevent conversion of the labile form of the S protein. If the vaccines didn't work together then one or both of them wouldn't work at all.
[ Parent | on HN ]
Re:Canada's 'gamble' on delaying, mixing and matching Covid-... by bserge on Sunday October 10, 2021 @05:53AM (#28817140)
Even better? Immune system learns of two (slightly) different ones, making immunity more robust.
[ Parent | on HN ]
Re:Canada's 'gamble' on delaying, mixing and matching Covid-... by refurb on Sunday October 10, 2021 @06:23AM (#28817264)
That’s the logic, and the argument why actual infection with Covid produces an even better immune response than mixed vaccines.

But that’s by no means a guaranteed outcome. Mixed vaccines could have resulted in mediocre immune response to two different spike protein profiles.

[ Parent | on HN ]