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Re:The curious DNA circles that make treating cancer so hard by ncmncm on Saturday October 02, 2021 @07:21PM (#28733042)
What it doesn't say is whether the "DNA circles" or "double minutes" have any role in normal cell activity

Except, they seem to have that in yeast, which are distinguished by a need to reproduce fast like tumor cells. If they have been ignored all this time, maybe they are just a normal part of eukaryote biology?

Re:The curious DNA circles that make treating cancer so hard by beowulfey on Saturday October 02, 2021 @09:11PM (#28733680)
Yes the recent paper [1] that confirmed they were circular mentioned the similarities to plasmids in bacteria too!

In the nematode world, we create extrachromosomal arrays of transgenes by injecting plasmids into the worm’s gonad that then get passed down to progeny; the expression we see is almost always variable and mosaic and not every cell ends up showing it.

I would guess this technique used for decades in the field is actually an induced version of these!

[1] https://www.nature.com/articles/s41586-019-1763-5

Re:The curious DNA circles that make treating cancer so hard by djmips on Sunday October 03, 2021 @06:39AM (#28736076)
One of the articles posted suggests that weeds use DNA circles to quickly adapt to herbicides.