So even with an engine designed to be most efficient when the car drives 65 mph, the efficiency of the system will quickly be controlled by drag forces as speed increases.
Unlike older scientific topics that have esoteric terminology, usually from the Latin, this one is pretty straight forward... It is the energy lost due to pumping. Basically, the overhead of keeping an engine running no matter how much distance of roadway you cover, but more on point, the extra losses due to running an engine outside of its peak power/performance range:
https://www.cycleworld.com/2015/10/12/ask-kevin-what-is-pump...
Not "pumping" losses, no. There is no intake air or exhaust gas to pump.
EVs may experience an effect that is similar in practice, albeit much smaller... Things like headlights, HVAC, entertainment systems, etc., will draw more power the longer it takes you to get to your destination, so reducing your speed from 30 to 15 MPH might not be an efficiency win.
Which is why hybrids often switch from electric to gas past some determined speed.
https://afdc.energy.gov/data/10312