I’ve had great success using PyQt for quite sophisticated GUIs. Any of the native bindings should give good results too. I doubt JS would give you more flexibility and performance than these.

I have found DearPyGui [1] to be a really efficient way to knock up a quick GUI for a Python script/app. There's almost no boilerplate and I've found it scales reasonably well as things get more complex as it's easy to split views/"components" into modules and classes.

[1] https://github.com/hoffstadt/DearPyGui

I've been very happy with using Qt and PySide and now PySide2.

Without it I couldn't have produced Captain's Log, for example : https://captainslog.scarygliders.net/captains-log-2/

This is exactly what happened with my home dashboard.

The initial version, 5 or so years ago (maybe a bit more, I do not remember) was based on a python library (sorry, I forgot the name but it was the major one at the time). It worked fine for a bit but moving to a kiosk browser and vue.js completely changed the game.

The backend was Python, then got replaced by a bus (mqtt) updated via golang microservices (they were in python initially, but then I wanted to learn go)

For most applications in my company, we prefer fastapi + Jinja to generate HTML pages, and rely on the browser to display that for us. For the few programs that need to be run locally & without browser, we use PySide2 (Qt bindings): the framework is bulkier, but somehow feels more reliable.