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Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by twofornone on Monday September 20, 2021 @05:48PM (#28599434)
>So, perhaps unsurprisingly, if you've had the virus and then received a vaccine, it appears that you have a very high level of immunity

Why would someone get vaccinated post infection?

Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by oskarpearson on Monday September 20, 2021 @06:09PM (#28599665)
For the same reason most vaccines require two doses. And for the same reason some countries are planning or doing booster shots.

Antibody levels drop rapidly after an infection, if they persist at all.

Getting a vaccination after infection re-triggers the immune system and makes antibodies more likely to persist for longer.

Reading up on this many months ago it seemed likely that natural infection plus a single vaccination would be equivalent to two vaccine shots.

There was research about only needing to give one shot of vaccines like AstraZeneca to people with previous infection. It was considered too complex to manage, and the research as to efficacy wasn’t finalised, so they stuck with two.

Having had Covid, plus two shots of something like AstraZeneca is presumably somewhere in the region of a standard two-shot-plus-booster campaign.

I don’t really understand much of this paper, but given other comments it seems to be a reasonable idea.

Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by gameswithgo on Monday September 20, 2021 @05:49PM (#28599438)
For more robust immunity, many people do this.
Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by ngvrnd on Monday September 20, 2021 @05:51PM (#28599466)
it is in fact recommended.
Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by scoot on Monday September 20, 2021 @05:59PM (#28599560)
But apparently not effective in all cases. A friend of mine in their early 20s has Covid a second time, having been vaccinated after their first infection.

(To catch it once is unfortunate...)

Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by amirhirsch on Monday September 20, 2021 @06:18PM (#28599766)
I don't know why your comment bothers me so much, but...

No, your friend didn't have COVID a second time after being vaccinated after their first infection. Especially lacking any clarification that they were in fact tested positive both times, you are merely contributing to noise on the internet.

1) "a friend of yours" is not a data point on which others should base their worldview (unless their testicles got huge and their fiance called it off, why even share?)

2) reinfection is rare

3) it is likely the first time they think they had covid, they weren't tested, and actually had the flu.

Here is the CDC information on reinfection: https://www.cdc.gov/coronavirus/2019-ncov/your-health/reinfe...

As of August 6, 2021, the CDC has nothing conclusive to say on the matter: "Cases of reinfection with COVID-19 have been reported, but remain rare . "

Anecdotes are noise, and I would encourage you to do no further research.

Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by scoot on Saturday September 25, 2021 @06:22PM (#28656679)
> No, your friend didn't have COVID a second time after being vaccinated after their first infection.

PCR tested positive both times, double jabbed in-between. You might not like the fact that it's possible, but that doesn't make it impossible.

1) You seem to be the one projecting a world view based off an anecdote. Chill.

2) Law of large numbers. A small percentage of a very large number is still a large number.

3) Here you go again with made up "facts" that aren't even anecdata.

> Cases of reinfection with COVID-19 have been reported

Seems pretty conclusive. They're referred to as "breakthrough cases", and not as rare as you seem to believe. What's more important is that the risk of hospitalization and death in breakthrough cases is considerably reduced.

> I would encourage you to do no further research

I would encourage you to do more. Making up "facts" to make a point does nothing to strengthen your position (whatever that may be – seems more like you just wanted to rant).

Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by bsder on Monday September 20, 2021 @06:23PM (#28599817)
A vaccine doesn't prevent you from catching a virus again--especially if you get a big bolus.

It does mean that your body is prepared to sweep the virus out faster and prevent it from spreading as far in your body.

In computer terms, a vaccine reduces the latency between when your body gets a virus and when it reaches critical immune response to get the virus under control.

So, for example, while you may get Covid in your nose, being vaccinated means that it doesn't get down into your lungs and heart and cause damage down there (the issues that cause most people to be hospitalized).

Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by rednerrus on Monday September 20, 2021 @06:03PM (#28599604)
But these are outliers, right?
Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by bsder on Monday September 20, 2021 @06:19PM (#28599781)
Because your immune system isn't guaranteed to pick up on the most relevant part of a pathogen.

While lots of people got diseases like smallpox and measles only once, others would get them several times. The difference is what part of the virus your antibodies selected to attack.

The spike protein seems to be both extremely important to SARS-CoV-2 and relatively unchanging.

If your body creates antibodies to it, you will have immunity on par with the vaccines.

If your body doesn't create antibodies to it, you have a mixed bag of immunity. Getting a vaccine buffs that up.

Immune systems are very buggy learning systems. This is good from a species survival perspective, but not always for a specific individual.

Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by dougmwne on Monday September 20, 2021 @06:25PM (#28599835)
It is currently recommend, and studies, such as this one, show that you will be highly protecting yourself from future variants you would have otherwise had low immunity against.
Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by xtorol on Monday September 20, 2021 @05:52PM (#28599468)
Why wouldn't they?
Re:High genetic barrier to SARS-CoV-2 polyclonal neutralizin... by dnautics on Monday September 20, 2021 @05:58PM (#28599549)
there are of course unknown risks associated with putting anything into your body. But it's probably still a good idea.