Melatonin: Much More Than You Wanted to Know (2018)

Re:Melatonin: Much More Than You Wanted to Know (2018) by polskibus on Monday September 06, 2021 @03:40AM (#28431391)

I always wonder if some of the self reported dosage variability for pills comes from differences in absorbtion of pills. Maybe some ppl's stomach acids or bacterial flora destroy particular molecules more or prevents absorption more than in other ppl?

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Re:Melatonin: Much More Than You Wanted to Know (2018) by xvedejas on Monday September 06, 2021 @04:07AM (#28431538)

Sublingual tablets are available which result in a much more reliably fast absorption. I recommend them for anyone who wants less variability from their melatonin use.

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Re:Melatonin: Much More Than You Wanted to Know (2018) by polskibus on Monday September 06, 2021 @10:51AM (#28434225)

Any links on why are sublingual better wrt absorption?

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Re:Melatonin: Much More Than You Wanted to Know (2018) by nextaccountic on Monday September 06, 2021 @01:43PM (#28436113)

It bypasses the stomach and intestines. It also bypasses liver metabolism (first-pass metabolism)

https://en.wikipedia.org/wiki/Sublingual_administration#Prin...

https://en.wikipedia.org/wiki/First_pass_effect

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Re:Melatonin: Much More Than You Wanted to Know (2018) by relaxing on Monday September 06, 2021 @01:38PM (#28436067)

Short answer is because the chemical goes directly through the membrane into the bloodstream.

https://en.m.wikipedia.org/wiki/Sublingual_administration

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Re:Melatonin: Much More Than You Wanted to Know (2018) by glanard_frugner on Wednesday September 08, 2021 @08:34PM (#28464787)

you can see this with pot edibles, if you take one on an empty stomach it takes forever to kick in and sometimes doesn’t work very well, but if you eat the same one after a large fatty meal it will kick in fast and strong

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