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A comment on Melatonin: Much More Than You Wanted to Know (2018). Parent comment

Re:Melatonin: Much More Than You Wanted to Know (2018) by polskibus on Monday September 06, 2021 @10:51AM (#28434225)
Any links on why are sublingual better wrt absorption?
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Re:Melatonin: Much More Than You Wanted to Know (2018) by nextaccountic on Monday September 06, 2021 @01:43PM (#28436113)
It bypasses the stomach and intestines. It also bypasses liver metabolism (first-pass metabolism)

https://en.wikipedia.org/wiki/Sublingual_administration#Prin...

https://en.wikipedia.org/wiki/First_pass_effect

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Re:Melatonin: Much More Than You Wanted to Know (2018) by relaxing on Monday September 06, 2021 @01:38PM (#28436067)
Short answer is because the chemical goes directly through the membrane into the bloodstream.

https://en.m.wikipedia.org/wiki/Sublingual_administration

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