"Nothing matters" - that's a very soothing thought. It's soothing because we all focus of what we haven't / couldn't done. It's human mentality to think of bad things over good things. So if nothing matters, then our bad things don't matter, and so it's soothing.

But I don't think we should base our life on any 1 particular ideology because of the possibility of us being wrong. Imagine someone basing their entire life on 1 particular ideology , and it turns out that they were simply wrong. The sunk-cost fallacy would be unbelievable.