It does matter. The arrow key cluster and numpad take a lot of space, which means the left side of the keyboard (where asdf / your left hand are) and your mouse have to be very far from each other. This leads to either putting the keyboard's letter key section in the center, making your mouse be uncomfortably far to the right, or having your mouse in a natural position for your right hand, leaving your left hand way out to the left. Over time this can (and did, to me) cause posture / muscle balance issues.
Currently I'm using the Microsoft Sculpt Wireless keyboard. https://www.microsoft.com/en-ww/accessories/products/keyboar.... The main keyboard with letters and two extra columns just to the right of the letters (with no gap) means everything can be positioned perfectly. The wireless numpad is there for when you need to use it. It's a very overpriced product at $100 but works wonderfully.
Also, in college I had a tiny desk with a cabinet underneath its left side, so my chair was offset to 60/40% of the way to the right. With a full size desktop keyboard with numpad, there literally wasn't enough space for my mouse, unless I moved the keyboard very far to the left. Thus causing the issues I mentioned above. That's what got me into tiny mechanical keyboards :) I'll admit it's a somewhat niche case, but there are probably still many millions of people in the world with a similar desk setup to that for whom a full size desktop keyboard is an unhealthy option.
Especially considering that nowadays "docking" is pluggin in an USB-C cable from a monitor that: - is used as a large external display - powers and recharges the laptop - acts as an USB hub, with external keyboard, mouse and webcam.
If I want I can go outside to have a meeting and when I want to code, I go back to my home office. And when I commute to the work office, I can work on the train. And when I get there, I plug it in the same setup as home. Next step would be having all of this wireless but it's already near perfect IME.
I just described my setup actually :)
I also did practice my musscle memory for the numpad in a similar way to touch as part of typing scientific data (back in the 90s). After a couple of weeks of that, my speed on the numpad would be at least twice as high as when typing numbers on the main keyboard. Also, accuracy was high enough that I could reliably trust the output even when not looking at the result (very close to 100%), which is critical for many use cases that involve numbers.
Even if I spend 99% of my time on the regular keyboard now, if I have to spend more than 5mins typing only numbers, I will feel really frustrated without a numpad.
Then again, I tend to use the laptop keyboards quite little anyway, mostly only while travelling or when in a meeting room. In the office, there is a dock and at home I use a desktop.
Personally in the never use it camp, and hate these offset laptops. Sometimes its because people do a lot of number data entry spreadsheet style, I can understand that case a little more, however even people that mostly type text I've seen for example will like to enter IP addresses on the number pad for no obvious reason. God speed IPv6 adoption :)
On the other hand laptops are terrible for ergonomics and daily usage anyway, it's unfortunately we've moved so far into laptops from desktops and it doesn't seem so common to dock them and use an external keyboard.. to my feeling mostly because the screen ends up being too small once you push it back to use an external keyboard so then you need an external monitor and the cost and complexity goes up.