Re:The Coronavirus Is Here Forever
by superkuh on Monday August 23, 2021 @11:40AM
(#28277527)
It is not because of the new variants and antibody escape. Prior variants before delta, gamma specifically, actually escape antibody neutralization far more than delta does.
No, what the world is seeing is that intramuscular vaccination for respiratory diseases does not provide long lasting IgG antibodies to the upper respiratory mucosa tissues. They seep into the lower lungs and provide protection there though. This has been known since the 1960s when the first intranasal flu vaccinations were introduced to combat the problem.
It wouldn't matter what variant is going around, it just happens to be delta now. The problem is the lack of persistent IgG antibodies in the surface mucosal tissues. To get long term protection from infection of these you need intranasal vaccination to recruit resident B and T cells to the mucosa to make IgA antibodies. Intramuscular does not prevent spread, it only prevents hospitalization and death. This is also true for intramuscular flu vaccination.
No, what the world is seeing is that intramuscular vaccination for respiratory diseases does not provide long lasting IgG antibodies to the upper respiratory mucosa tissues. They seep into the lower lungs and provide protection there though. This has been known since the 1960s when the first intranasal flu vaccinations were introduced to combat the problem.
It wouldn't matter what variant is going around, it just happens to be delta now. The problem is the lack of persistent IgG antibodies in the surface mucosal tissues. To get long term protection from infection of these you need intranasal vaccination to recruit resident B and T cells to the mucosa to make IgA antibodies. Intramuscular does not prevent spread, it only prevents hospitalization and death. This is also true for intramuscular flu vaccination.