The challenge of course is that if there is no penalty for doing something harmful to a portion of the population, then people will keep doing it - probably indefinitely.

It might be easier to think of it as a evolutionary process. Adding in things like (enforced) laws around making space for wheelchair clients for a business will select against those that don't do it. That will inevitably result in churn (and cycle of life death/rebirth and associated pain and loss), but as long as there is sufficient presence of the 'species' (to extend the analogy) that does what you want, then it's the equivalent of weeding a garden. Sucks to be the weed, but if no one does it, it turns into a giant mess of bad stuff and everyone loses.

It's also important to not starve by 'weeding out' all your crops. It's a balance.