Depending on where your office is (typically some sort of city) this can actually be pretty dangerous (hit+run, crime, breathing very unhealthy air). Conversely if you work remotely, you can live in the suburbs or even somewhere more remote.

Additionally, I know in many in-person orgs leaving to go outside and smoke is super frowned upon and seen as a productivity drain. I assume "going for a quick run" would have the same effect at your off-the-shelf toxic org. In a remote org, no one is going to be breathing down your neck while you take 15 mins to go for a walk to collect your thoughts. Especially if we keep passing privacy legislation that limits the ability of the Amazons of the world to install spyware on worker machines.