I generally suffer exclusively the singular negative effect of others finger wagging and disapproval of a rather pleasurable funcional vice or medication or whatever you wish to call it.

I’ve quit a few times for up to a year and always decided consciously to go back. One of the times I left tobacco behind. Countless studies will only ever have access to what users are willing to divulge, to the degree that it’s not an open regulated or at least informed market.

There is an interesting singular fact. Not one single overdose death has ever been conclusively linked to cannabis. The LD50 is something crazy like 15kg in the span of 15 minutes for a 75kg human.

A practical application of this is to suggest that those who want to use cannabis for a good night;s sleep, get started two or three hours before bedtime.

I got twenty excellent years out of regular cannabis use. Tradeoffs there were, but worth it.

I'm a lot more sensitive now and sometimes it gives me panic attacks. But even when it doesn't, cannabis consistently raises heart rate and lowers blood pressure, that's just how it works.

I still employ it, carefully, from time to time.

Have you tried using the minimal amount of very low-potency weed?

In my experience negative effects like paranoia and panic attacks come from overdose, either by using high-potency weed and/or smoking too much.

Panic attacks are well under a 1 in 20 response now or I just wouldn't bother, since it isn't any fun at all for about 20 (subjectively very long) minutes.

I have what's called a paradoxical reaction to whatever they use to put you under anesthesia. I wake up in a rage, they have to take me out very slowly.

I have a friend like this with marijuana. She finds indicas make her euphoric and energized and creative, when she should be couch-locked with a body high. Until she swapped types she kept getting super anxious and it led her to bad trips. But the benefits outweighed the downsides for her (she was able to eat and sleep normally).

Also- coughing (which you almost certainly will), will raise your heart rate.

So how do we know what is a bad effect of the plant in general? This is worrying to me, and as a marijuana smoker I would really love more studies to be done on it.

Euphoria and relaxation aren't identical concepts...

Just saying 'marijuana did this to me' without context of the strain or if it was constant across strains isn't super helpful.