2) Mixing Ox/Az w/ mRNA vaccinations has been shown to be better than 2x Ox/Ax [1]
3) Pfizer, Moderna, AZ/Covishield, and J&J are the only approved vaccines. Certainly no "soup of the day" [2]
I hardly think any of this is "cringe".
[0] https://www.canada.ca/en/public-health/services/diseases/201...
[1] https://www.cbc.ca/news/health/mixing-vaccines-pfizer-astraz...
[2] https://www.canada.ca/en/public-health/services/diseases/cor...
Source: google it
https://health-infobase.canada.ca/covid-19/vaccination-cover...
After the initial safety trials showing that these vaccines have no significant adverse effects, we should have just gotten a dozen YOLO engineers and statisticians to run any permutation of dosage, duration, and vaccine candidate; much like how software companies run thousands of A/B tests at scale.
It's a frigging pandemic with millions of deaths, there's no time to waste jacking off bureaucrats.
Really, there's no good reason that clinical trials should cost $$$$-$$$$$ per participant. Here's how much it should cost:
~$20: targeted ads enrolling one participant
~$20: doses of the vaccine for one participant
~$30: distribution and logistics
~$100: human staffing and follow up
~$5: experiment analysis
Instead, everything gets ballooned up by 10x or 50x because of arcane legislation. In the middle of a global pandemic.
> There exists in such a case a certain institution or law; let us say, for the sake of simplicity, a fence or gate erected across a road. The more modern type of reformer goes gaily up to it and says, “I don’t see the use of this; let us clear it away.” To which the more intelligent type of reformer will do well to answer: “If you don’t see the use of it, I certainly won’t let you clear it away. Go away and think. Then, when you can come back and tell me that you do see the use of it, I may allow you to destroy it.”
I, for one, would try to run clinical trials the total opposite from software companies.
"Fail fast, fail often" nor "Iterate fast, release often" really work for healthcare.
In Canada, Astrazeneca was available to anyone who wanted it if you wanted to skip the line for mRNA and be vaccinated immediately. Originally this was before the (likely overblown) health concerns with Astrazeneca.
As a Canadian, I found the roll out to be quite organized. The original promise was that all Canadians would have access to a vaccine by September and it looks like we will meet that goal handedly. I wouldn't call it a disaster at all. But then I don't live in Ontario.
The mix of vaccine shots doesn’t bother me.
Indeed comparing and following the USA is a problem.
The rules changed all the time and with no explanation or justification. Government ministries didn't speak to one another or the regions. Multiple times the education minister said schools were opening while the premier said they were staying closed (or vice versa).
Vaccinations were delegated almost entirely to the regions and it was complete chaos, especially since the pharmacies were left to do all their own booking. I registered with the region and over 30 pharmacies to get my first dose. Then I got offers of first dose for more than a month after that I had to keep cancelling. 2nd dose was much more straight forward, but that was just luck since I know plenty of people who had to search and scramble.
The re-opening stages have minimal differences between them and don't offer any incentive to get vaccinated since there are no exceptions or enhancements for those fully vaccinated.
Government failed us pretty hard.
My experiences with the provincial registration system in Ontario, were the complete opposite of yours. They were very good. Once my demographic became eligible, it was a single form to book an appointment. The actual vaccine clinics were quite efficient, and the followup (if you opted-in) was quick and easy.
The hardest part was waiting. Vaccines supply was the issue, but given Canada’s bargaining position (essentially none?) I’m shocked we got them as quickly as we did.
It did!
Disclaimer: Canadian