The four-color theorem had the preliminary challenge of creating a method to identify all the relevant cases. That also required a mathematical theory. (I don't actually understand how it was done!)

If you didn't have that, you would have an infinite search for possible maps that violate the conjecture, because you wouldn't be able to divide them into a finite number of equivalence classes, or enumerate a finite number of possible counterexamples, or whatever.

For Collatz, I don't think we have any lemma that gives a path to saying "a counterexample must be one of these 2¹⁰⁰ integers" or the like. So without such a thing, checking every possibility would mean checking every integer. (Well, there are definitely lemmas that make it unnecessary to check large numbers of integers, so I should say instead that checking every possibility would still mean checking an infinite number of cases.)