It seems that there is some correlation between cardiovascular risk and blood donation, but this might just be due to a confounding factor: healthy people tend to donate blood more.
E.g. this study [1]:
Despite the significant difference in QRISK2 parameters between study groups, none of these parameters was correlated to the extent of donation when controlling for age, BMI and smoking status.
Or this one [2]:
No significant associations were found between blood donation and the risk of myocardial infarction in analyses restricted to men with hypercholesterolemia or those who never used antioxidant supplements or aspirin. The study results do not support the hypothesis that reduced body iron stores lower CHD risk.
Ironically this other Dutch study [3], shows an association (not causal) between frequent blood donation and cardiovascular health in women but not in men.
[1]: https://pubmed.ncbi.nlm.nih.gov/28797569/ [2]: https://www.ahajournals.org/doi/full/10.1161/01.cir.103.1.52 [3]: https://heart.bmj.com/content/105/16/1260
Once women reach the age of 50, about the age of natural menopause, their risk for heart disease increases dramatically.
https://www.webmd.com/menopause/guide/menopause-heart-diseas...
Wouldn't the hormonal changes associated with menopause be a more likely explanation for the increase in heart disease risk than the fact they are no longer losing blood periodically?
The average lifetime risk of developing cardiovascular disease was around 52% for men and 39% for women.
Lifetime risk jumped to 69% for men and 50% for women who had two or more cardiovascular risk factors by age 50.
Lifetime risk was just 5% among men and 8% among women who had optimal risk factors for cardiovascular disease at age 50.
https://www.webmd.com/heart-disease/news/20060206/how-great-...
Studies have shown that, in general, Americans tend to consume more iron on a daily basis than is necessary for good health. Ingestion of quantities of iron beyond a certain quantity can promote formation of free radicals in the body. Free radicals have justly earned their reputation for causing cellular changes which can disrupt normal cell function and increase the risk of certain chronic diseases such as heart disease and cancer. This is more likely to be a problem for men and post menopausal women...
https://medicalwesthospital.org/january-is-blood-donor-month...
I'm American. If you aren't, that might be a factor.