News for hackers. Stuff that matters.
Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by kube-system on Sunday June 27, 2021 @03:00PM (#27654224)
This is good news regardless, but I wish these articles had more detail. Some number of "% effective against COVID-19" is not meaningful on its own. Effective at doing what, exactly? Preventing symptoms? Preventing transmission? Preventing death?

Comparisons between different vaccines aren't at all meaningful without this context, and I hope the authors realize this, despite not mentioning it.

Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by vidoc on Sunday June 27, 2021 @03:15PM (#27654362)
> Effective at doing what, exactly?

I think at this point all the 'efficacy' numbers given by drug companies for the various vaccines on the market are: relative risk reduction of hospitalization or death.

Not uninteresting per se, but would be even more interesting if paired with the absolute risk number [1].

1: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996517/

Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by perlgeek on Sunday June 27, 2021 @04:33PM (#27655024)
There are basically 4 effectiveness numbers, based on whether you measure:

* positive PCR tests

* showing symptoms

* hospitalization

* death

I share kube-system's frustration with the media glossing over those details quite often.

Here in Germany, there were numbers thrown around such as the mRNA vaccines being 90%+ effective, and the AstraZeneca being only in 60ies or 70ies (which was likely based on PCR tests). Which made many Germans hesitant to get that vaccine.

Turns out, AstraZeneca prevents hospitalization at a roughly 90% effectiveness rate (recent numbers from England, don#t have link ready right now), which sound much better than 65% number.

Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by baix777 on Sunday June 27, 2021 @08:28PM (#27656802)
A recent study put the Pfizer vaccine at a 97% hospitalization prevention rate, which is much better than the AZ one. How comparable all these studies is a good question.

https://www.cidrap.umn.edu/news-perspective/2021/05/real-wor...

Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by maxerickson on Sunday June 27, 2021 @09:20PM (#27657117)
The US vaccines use a different spike protein than the AZ vaccine. It's likely that they are truly more effective.
Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by ec109685 on Sunday June 27, 2021 @03:40PM (#27654591)
Absolute risk will ebb and flow with the abundance of the virus in a population, so it wouldn’t be useful as a comparison or as a predictor for the future since every trial will be different.
Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by alister on Sunday June 27, 2021 @09:54PM (#27657317)
I skimmed the article you linked to[1], but I still don't understand the advantage of using the absolute risk reduction rather than the relative risk reduction (or the point of reporting both). It seems it's like the same information expressed differently. I'm guessing that there must be an intuitive advantage like measuring the fuel economy of a car in gallons per 100 miles rather than the usual miles per gallon, but I'm not seeing it. Can you explain further?

[1] Quoting the article's explanation of AAR vs RRR: "The vaccine and placebo groups in Figure 1 each have 100 randomly assigned individuals with no history of infection, and an event is defined as the incidence of infection among all individuals during the course of the trial. The percentage of events in the vaccine group is the experimental event rate (EER) or the risk of infection in the vaccine group (1/100 = 1%), and the percentage of events in the placebo group is the control event rate (CER) or the risk of infection in the placebo group (2/100 = 2%). Absolute risk reduction (ARR) is the disease risk difference between the placebo and vaccine groups, i.e., the CER minus the EER (2% − 1% = 1%). The ARR is also known as the vaccine disease preventable incidence (VDPI). Relative risk reduction (RRR) or vaccine efficacy (VE) is the reduced risk from vaccination, the ARR or VDPI, relative to or divided by the risk in unvaccinated individuals, the CER (1%/2% = 50%)".

Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by vidoc on Monday June 28, 2021 @12:03PM (#27663623)
> I'm guessing that there must be an intuitive advantage like measuring the fuel economy of a car in gallons per 100 miles rather than the usual miles per gallon, but I'm not seeing it. Can you explain further?

Sure, ARR is more interesting for risk/cost benefits analysis. So much so that it is part of the official FDA guidelines expressed in this document ("Communicating risks and benefits: An evidence based user guide" [1]).

"Another statistical choice is between reporting relative or absolute risks. Because there is no way to infer the latter from the former, absolute risks are always more informative. Doubling a risk means very different things if that entails going from 10% to 20% or from 0.001% to 0.002%.Even when they contain the same information, different summaries can highlight different perspectives, hence bias choices."

Besides, if you compare the ranks of the main vaccines in each stat, you can see that it is not the same information expressed differently:

ARR: AZ 1.3%, Moderna 1.2%, J&J 1.2%, 0.84% Pfizer RRR: 95% Pfizer, 94% Moderna, 67% J&J, 67% AZ

1: https://www.fda.gov/media/81597/download

Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by smnrchrds on Sunday June 27, 2021 @11:14PM (#27657714)
I share your skepticism. Personally, I have talked to people (educated and intelligent people) who refuse to get the vaccine because "it is only ~1% effective". Using ARR seems to cause more confusion and misunderstanding that RRR.
Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by andrewseanryan on Sunday June 27, 2021 @05:10PM (#27655393)
My understanding is that “effectiveness” in these studies means that it is x% effective at preventing covid-19. So comparing these numbers is not the most important thing. Most all of the vaccines on the market are very, very effective at stopping death and hospitalization, which is the most important thing.
Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by kube-system on Sunday June 27, 2021 @05:17PM (#27655484)
> preventing covid-19

That could still mean several different things.

I'm not questioning whether or not any of them are effective enough to be useful. I got the first one I could. I'm questioning whether or not the comparisons that others are making are meaningful.

Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by stjohnswarts on Monday June 28, 2021 @02:13AM (#27658655)
I think you can safely assume it means it's good are preventing a non to minor reaction to the virus in 92% of the cases, and be close enough. That's rather meaningful. It's no reason to say "this article is useless"
Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by ufo on Sunday June 27, 2021 @04:03PM (#27654768)
I'd say the opposite: maybe the news reports should have less detail. The efficacy percentages of different vaccines mean different things but the way they have been publicized has lead many people to think one vaccine is better than the other. We're starting to see some people refuse to get vaccinated, because they're shopping aroung for a vaccine that they think is more effective. At the end of the day, what really matters is vaccinating as many people as soon as possible.
Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by skocznymroczny on Sunday June 27, 2021 @04:14PM (#27654882)
I disagree. Hiding data from the public in the name of public good has been the basis of every censorship throughout history.
Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by ufo on Sunday June 27, 2021 @04:48PM (#27655178)
I don't see a problem with the information being available. But in my opinion it shouldn't be in the headline. IMO, it would be better if the headline just said that the vaccine is safe and effective.
Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by kube-system on Sunday June 27, 2021 @04:51PM (#27655198)
While I share your frustration with the general public's opinion on vaccination, I don't think that the idiots who can't comprehend the details would be convinced with fewer details. Those people aren't paying attention to the details anyway.

For instance, when the J&J clot "issue" hit the news cycle, vaccinations across the board went down, even for vaccines other than J&J. These people aren't looking at any kind of details or data and getting confused by them, they're just making a decision based on word-of-mouth sentiment from their social/media circles. They would have never been confused by details in the article, because they never read it.

Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by pyuser583 on Sunday June 27, 2021 @10:21PM (#27657451)
I agree - way too many people think they know what they’re talking about. Data is only helpful if you know how to use it.

The data should be publicly available, but that doesn’t mean it belongs in an article for general consumption.

Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by int_19h on Sunday June 27, 2021 @10:50PM (#27657589)
And how would you achieve that? If data is publicly available, somebody somewhere will decide to write an article based on it. And if it sounds interesting, it will spread.
Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by pyuser583 on Monday June 28, 2021 @12:47AM (#27658214)
In just saying it’s not a good editorial decision to include excess data in an mainstream news article.

If a more specialized publication wants to offer a more explanatory story, fine.

But I don’t think that’s what people are looking for from a regular newspapers.

Knowing a vaccine is considered by experts to be effective is sufficient. The exact rates of reinfection aren’t important and can be confusing.

Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by effie on Monday June 28, 2021 @05:37PM (#27668516)
> Knowing a vaccine is considered by experts to be effective is sufficient. The exact rates of reinfection aren’t important and can be confusing.

Sufficient to whom? Experts often disagree and if they disagree, I want to know where and why and what the data is. Just because I am not expert on the topic does not mean I can't make judgements on incomplete information.

You are seriously underestimating people that may want to read mainstream sources, as if they need to be told what to think.

True, MSM unfortunately regularly does that instead of impartial reporting, but how could anyone be a proponent that all MSM articles being like this is desirable for informed society. The increased focus on narrative pushing from MSM is the source of distrust in MSM and the reason why people turn to alternative sources.

Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by int_19h on Monday June 28, 2021 @08:16AM (#27660866)
In a free media market, editorial decisions are made based on audience engagement. If the readers are more likely to read the article with more numbers (and thus see the ads in it), that's what will be published.
Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by pyuser583 on Monday June 28, 2021 @04:06PM (#27667199)
In a free market, editorial decisions are made based on advertising revenue.

That’s not always a good thing. Simply because something is factually true and increases audience engagement doesn’t mean it’s relevant or responsible to include.

For example, COVID had a fatality rate of 2%. That’s a fact. It also will increase engagement amount certain media markets.

But that’s also very misleading. 2% of the world is 140 million people.

The fact that it’s piece of “true data” that increases audience engagement doesn’t mean it belongs in mainstream articles.

Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by manwe150 on Tuesday June 29, 2021 @12:58AM (#27671960)
Isn’t that 2% of CFR (particularly also hospitalizations), not IFR? Still many people (and thus is the reason that historically regions of the US, dating back to George Washington, mandated some vaccines), just not the whole world.
Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by int_19h on Tuesday June 29, 2021 @12:30AM (#27671774)
Oh, I'm not saying it's a good thing. I just don't see what you can do about it within a capitalist framework without some kind of centralized censorship - which is even worse in the long run.
Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by pyuser583 on Tuesday June 29, 2021 @08:01AM (#27674643)
I don’t think misleading data increases user engagement that much. And editors usually do a pretty good job not naming victims of sexual assault, reporting in suicides, etc.

Most editors want to maintain high standards, and that means excluding irrelevant data.

Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by effie on Monday June 28, 2021 @05:25PM (#27668353)
> At the end of the day, what really matters is vaccinating as many people as soon as possible.

This position is absolutist and a mark of a totalitarian thinking and a large portion of population does not share it.

For most people, individual people freedoms matter too and in democracy, these freedoms are stronger than the institutional desideratum to vaccinate as many people as technically possible. What is best for the whole country isn't always best for the individual living there.

Re:Cuba′s Covid vaccine rivals Pfizer, Moderna by manwe150 on Tuesday June 29, 2021 @12:53AM (#27671923)
Curiously, I recently learned that George Washington imposed a mandate on the troops that required them to get the new vaccine, the first ever such idea. This means we owe the existence of our freedoms to mandatory vaccinations.

https://www.history.com/.amp/news/smallpox-george-washington...