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Re:CRISPR gene-editing breakthrough opens door to treating b... by rolleiflex on Saturday June 26, 2021 @05:54PM (#27646272)
It’s editing the genes of the cells of the liver, so presumably when those liver cells divide and multiply, the change would also be copied along as well.

What isn’t clear to me is that if this is targeted at the liver cells in particular, or splicing it for every cell in the body. In other words, this could be a germline mutation (passed to children) or it could be a somatic mutation (no change to future children), it depends on how targeted the treatment was.

Re:CRISPR gene-editing breakthrough opens door to treating b... by wgolsen on Saturday June 26, 2021 @06:27PM (#27646534)
When administered IV, most LNPs of this type are highly selective for hepatocytes. This edit cannot be passed on as no germ cells will be transfected.
Re:CRISPR gene-editing breakthrough opens door to treating b... by kaba0 on Saturday June 26, 2021 @06:00PM (#27646324)
Even if it is not specific, I would believe gametes are not affected/can be easily excludes due to the blood-testis barrier.