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A comment on CRISPR gene-editing breakthrough opens door to treating broad array of diseases. Parent comment

Re:CRISPR gene-editing breakthrough opens door to treating b... by noveltyaccount on Saturday June 26, 2021 @05:37PM (#27646127)
Is this a one-time treatment? Does it remove all of the offending genetic material, and then when those cells divide they are cured? Or does it require ongoing treatment?
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Re:CRISPR gene-editing breakthrough opens door to treating b... by rolleiflex on Saturday June 26, 2021 @05:54PM (#27646272)
It’s editing the genes of the cells of the liver, so presumably when those liver cells divide and multiply, the change would also be copied along as well.

What isn’t clear to me is that if this is targeted at the liver cells in particular, or splicing it for every cell in the body. In other words, this could be a germline mutation (passed to children) or it could be a somatic mutation (no change to future children), it depends on how targeted the treatment was.

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Re:CRISPR gene-editing breakthrough opens door to treating b... by wgolsen on Saturday June 26, 2021 @06:27PM (#27646534)
When administered IV, most LNPs of this type are highly selective for hepatocytes. This edit cannot be passed on as no germ cells will be transfected.
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Re:CRISPR gene-editing breakthrough opens door to treating b... by kaba0 on Saturday June 26, 2021 @06:00PM (#27646324)
Even if it is not specific, I would believe gametes are not affected/can be easily excludes due to the blood-testis barrier.
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Re:CRISPR gene-editing breakthrough opens door to treating b... by drran on Sunday June 27, 2021 @11:36AM (#27652389)
Patient will need to do it once per 1,5-2 years.

See https://www.youtube.com/watch?v=aoczYXJeMY4 .

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