I do use VS code as for some tasks there is no viable alternative for me and since my development workstation is a monster it runs fine. My own desktop apps however are native and I test them on really shitty hardware where one would not dream of running VS Code / Slack / whatever.
For fun I've compiled my main desktop product to 32 bit and it runs on a friggin old netbook just fine. Also from my point of view speed of development is not any slower when developing native applications. So unless client specifically requires it or I am doing some front end in browser my desktop apps are all native and coded in Delphi/Lazarus and my backends are C++.
The only time i saw a difference when i made a raytracer benchmark[0] explicitly to benchmark the codegen where the Free Pascal codegen at its best was at 177% of the speed of the Clang 8 at its best. In my experience this is not a realistic metric though (according to the benchmark my C 3D engine should be five times slower if compiled in BC++ than Clang but in practice since it does a variety more stuff than just a single thing the performance difference is barely perceptible).
My desktop products are made in Delphi (compiles to native code) and are very responsive and frugal on resources. Run fine on very old hardware. Desktop products done in C++ would be even better but I am not masochistic enough to develop GUI in C++. At least for now.