There is a major trade-off between convenience and security. Qubes is likely significantly more secure, but it is far, and I mean FAR less convenient.

Not a bad thing at all, I feel both have their place but they aren't comparable. Also you pretty much can't (shouldn't is more correct but when you do, you will feel it is closer to can't) run Qubes on the kind of low-end hardware many chromebooks ship with.