There are a lot of studies of varying quality, some of which show benefit for IVM and HCQ. One place to find some of these compiled is https://hcqmeta.com. Beware that they don't say what their study inclusion criteria is, so one has to be more skeptical of studies that have a small N and/or high P value.

The RECOVERY results for HCQ were definitely negative. Personally I'm neutral on its effectiveness, but HCQ proponents would probably say that HCQ's postulated antiviral mechanism is not effective on already hospitalized patients, since most of them would have already cleared the virus by the time they showed up to the hospital.

It's interesting to look at the forest plots on that page and only focus on RCTs, which are labeled. I cannot understand why someone would try to meta-analyze RCTs with observational studies when dozens of each exist. But this really hammers home (despite their misleading summary statistics at the top) that the evidence does not support an effect of HCQ on COVID-19.

Regarding ivermectin, this twitter thread does a good job summarizing other studies and links to them all.

https://twitter.com/AbdenurFlavio/status/1398717229366235141

Here's a pre print from today. Credible authors so I do expect it to go the distance: https://www.medrxiv.org/content/10.1101/2021.05.28.21258012v...

This expose on the suppression of ivermectin is telling: https://covid19criticalcare.com/wp-content/uploads/2021/05/T...

Lots of studies referenced in it.

Thank you for sharing the link. I do note that this is an observational study of 255 people. It contradicts a randomized trial with 1,561 people in the HCQ-arm alone vs 3,155 receiving usual care (RECOVERY).

When they are studied as a prophylactic or at early stage, they really prove out. I think that trial you referenced was in late stage severe cases, almost feels like they gamed that design to fail.

The study you have cited was entirely confined to 255 patients, all of whom required mechanical ventilation, 70% of whom died by day 90. That's severe COVID, not "prophylaxis."

Yeah I know, and I didn't expect that. It's even better the earlier it's applied though.