News for hackers. Stuff that matters.

A comment on Drug users use a lot of drugs. Parent comment

Re:Drug users use a lot of drugs by eurasiantiger on Thursday June 10, 2021 @04:28AM (#27458341)
Chocolate has a lot of PEA which activates the TAAR1 receptor just like amphetamines.

In fact, all amphetamines contain a PEA base - they are substitutes phenylethylamines, for example Alpha-MethylPHenEThylAMINE.

[ Parent | on HN ]
Re:Drug users use a lot of drugs by newbie789 on Thursday June 10, 2021 @12:59PM (#27462886)
The primary effect of amphetamines (that matters) is VMAT inhibition. While lots of drugs hit lots of receptors, and there are lots of overlap because of this, this does not make different compounds equivalent.

For example, off the top of my head, mescaline is also in the phenylethylamine family but is a wildly different drug with different receptor bonding affinity and subjective effects. I doubt anyone would want to mix up the two.

[ Parent | on HN ]
Re:Drug users use a lot of drugs by eurasiantiger on Thursday June 10, 2021 @01:12PM (#27463035)
You are correct. However, PEA alone does have a stimulant effect through TAAR1, and in chocolate it is coupled with other xanthine stimulants.
[ Parent | on HN ]