I'm not sure about most systems, but whatever Subaru puts in their cars works pretty well in my experience. It has a little trouble on windy mountain roads when the shoulder isn't well marked (it doesn't drive off a cliff or anything, but the autosteer disengages), but on the freeway I can usually go 10+ minutes without any manual interaction.

Autosteering / lane-centering (which is increasingly standard in driver assistance technology, including bluecruise which will be available on this truck) is not the same as lane-keep assist.