Yeah, personally, seems worth it. I've had a lot of good times drinking, and if it means my brain degrades 80bps more, well then so be it!

Everything has a cost and nothing is free and it's up to you to decide what decisions you are going to make. It really infuriates me when people think that a long and healthy life is something that we all should sacrifice everything for. As if the whole point of existence is to maximize those two metrics.