> By the same token, drinking alcohol in shots, cold and concentrated, is about the worst way to consume it, because most of it is then spent ruining the liver, and little actually reaches the brain. Sipping a glass of wine does not compare.

That really isn’t how alcohol works in the bloodstream. Once it’s through the GI tract there is zero difference in what the source of alcohol is. Further, the liver takes a long time to break down a shot of alcohol or a glass of wine. The only real difference is to the throat, stomach lining where more concentrated alcohol can be a larger irritant. But again once it’s in the blood stream it’s both significantly diluted and rapidly spread throughout the body.

Now sipping wine with food does significantly slow absorption, but it’s the same effect if you take a shot in the middle of a meal.