I guess part of it depends on what you personally have an issue with. But I can't see trading 40 hours of meaningless work for 80 hours of running my own business, or dropping out and living some nomad life. Or the constant hustle and living near poverty to be in arts or academic research .
Or they'll die of exposure on the streets, or worse. People, in general, can't be expected to solve fundamental problems of the distribution of wealth, opportunity, education, healthcare, food, property, knowledge, power, and comfort in our society by job hopping. The median job in America is a bullshit job for a petty dictator which is a direct result of terrible policy over decades.
The "or figure out something else to do" at the end of your comment is telling of these systemic problems, even if you did not intend it to be such a profound criticism of society and culture.
It's problematic when you can't make those changes, e.g. you're young and still living with/dependent upon parents, or you feel you'd have to give up too much e.g. being close to your kids, or people are telling you to just take a pill and it will be better.
IDK about psilocybin, never tried it, seems like more snake oil honestly, there are no magic answers here.
That doesn't sound plausible, as one of the main parts of depression is often debilitating lack of motivation (much more than sadness or anxiety). So depressed people are usually the least likely to be able to independently make any kind of significant change in their life - they're already spending most of their "energy" on getting out of bed and following a routine.
Not to mention, establishing clear routines and minor goals is one of the main recommendations (outside medication) for dealing with depression.
But instead of admitting that their life simply sucks, they are brainwashed into thinking that there must be something wrong with them.
It's part of the reason why psilocybin is so effective. It makes people actually realize that. That no amount of meds will fix it. That to be happy, you will have to change your life, get unstuck from all the things you don't really need, and prioritize happiness.