Try winevdm[1] or ntvdmx64[2], which I believe is based on leaked Microsoft source code. I've successfully gotten Tetris running on win10x64, and I'm happy enough with not needing dosbox+win3x for it.

1: https://github.com/otya128/winevdm 2: https://github.com/leecher1337/ntvdmx64