Association of sleep duration in middle and old age with incidence of dementia

Re:Association of sleep duration in middle and old age with ... by JamesBarney on Wednesday April 21, 2021 @02:31PM (#26893625)

https://pubmed.ncbi.nlm.nih.gov/20182054/#:~:text=In%20the%2....

this says coffee is associated with a reduced risk of dementia which is pretty much what I've read over and over again

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Re:Association of sleep duration in middle and old age with ... by eurasiantiger on Wednesday April 21, 2021 @06:44PM (#26896356)

That study conflates caffeine and coffee from the very first word in the abstract. I wouldn’t trust it at all — it’s like an article about CPUs but the writer doesn’t understand the difference between a processor (called CPU) and the rest of the stuff in the computer case (which, as a whole, is also called CPU).

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Re:Association of sleep duration in middle and old age with ... by jv22222 on Saturday April 24, 2021 @02:48PM (#26927334)

https://www.nature.com/articles/s41398-019-0604-5

Those studies reported higher coffee drinkers had 31–65% decrease in the risk of AD dementia, which is quite comparable to about 65% decrease of Aβ positivity rate in higher coffee drinkers (27.14%) compared to lower coffee drinkers (17.61%). Furthermore, the relationship between higher coffee intake and lower Aβ positivity was prominent for lifetime coffee intake than for current coffee intake. This suggests that the protective effects of higher coffee intake against Aβ pathology involve the chronic effects associated with prolonged exposure rather than an acute or short-term effect.

Note: "coffee drinkers" not "caffeine"

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Re:Association of sleep duration in middle and old age with ... by heavyset_go on Wednesday April 21, 2021 @11:01PM (#26898252)

So I read the whole paper, and not just the abstract. The authors do not conflate caffeine and coffee in the meta-analysis, in fact, they cite several studies that document the association between coffee consumption and the reduced risk of cognitive decline.

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Re:Association of sleep duration in middle and old age with ... by eurasiantiger on Thursday April 22, 2021 @02:38AM (#26899500)

Did you check whether those studies do this conflation? Were they epidemiological studies (which cannot prove causality), or double-blind randomized studies (which can)?

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Re:Association of sleep duration in middle and old age with ... by codyswann on Thursday April 22, 2021 @05:59AM (#26900834)

I think that burden falls on you since you're the one trying to discredit the study.

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Re:Association of sleep duration in middle and old age with ... by eurasiantiger on Thursday April 22, 2021 @08:25AM (#26901927)

Well, yeah. The studies were all longitudinal studies relying on self-reporting and some found an increased risk for >5 cups per day. Since a ”cup” is not a well defined measurement anyway, these are not very rigorous studies. It’s baffling that scientists so readily interpret these results to mean something, when it’s infinitely more likely they’ve missed some unexpected confounders.

I found no mention of MAO inhibitors, beta-carbolines or heterocyclic aromatic amines in coffee. The authors seem to be unaware of their existence, even though they could explain the results in many ways.

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Re:Association of sleep duration in middle and old age with ... by eloff on Wednesday April 21, 2021 @02:41PM (#26893762)

Thank you! I was freaking out about my beloved coffee addiction.

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Re:Association of sleep duration in middle and old age with ... by zikzak on Wednesday April 21, 2021 @03:05PM (#26894065)

Never blame the coffee.

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Re:Association of sleep duration in middle and old age with ... by eurasiantiger on Thursday April 22, 2021 @02:39AM (#26899504)

That seems like a cognitive bias.

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