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A comment on mRNA vaccines – a new era in vaccinology (2018). Parent comment

Re:mRNA vaccines – a new era in vaccinology (2018) by Fomite on Tuesday April 20, 2021 @11:44PM (#26885208)
mRNA does phase out - they're blueprints that are broken down when they're not needed. The half-life of them is measured in hours: http://book.bionumbers.org/how-fast-do-rnas-and-proteins-deg...

Edit: As noted in a comment, the half-life for the vaccine-related mRNA strands are longer, by design, so they produce more spike protein, but they remain fairly transient.

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Re:mRNA vaccines – a new era in vaccinology (2018) by hartator on Wednesday April 21, 2021 @12:02AM (#26885298)
Moderna and Pfizer mRNA half life is actually 10 and 14 days. The human one is indeed hours. Which is fine but it’s indeed not clear in their communication.
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Re:mRNA vaccines – a new era in vaccinology (2018) by franklyt on Wednesday April 21, 2021 @03:23AM (#26886391)
That’s a huge difference. Do you have a citation for this claim? I don’t doubt you, but, wow.
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Re:mRNA vaccines – a new era in vaccinology (2018) by inglor_cz on Wednesday April 21, 2021 @08:08AM (#26888515)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076378/

Look at the section 4.1. Molecular Stabilization. Yes, it is a challenge, but a challenge that has been overcome.

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Re:mRNA vaccines – a new era in vaccinology (2018) by hoseja on Wednesday April 21, 2021 @05:35AM (#26887281)
You can probably design the fragment so it doesn't mesh well with the recycling apparatus of the human cell but still works for transcription.
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Re:mRNA vaccines – a new era in vaccinology (2018) by throwawaysea on Wednesday April 21, 2021 @11:07AM (#26890619)
For GP’s comment, what happens to vaccine components that are “broken down”? It’s not just the mRNA in there right? There are other compounds to aid in delivering and stabilizing the dose. A serious side effect known only in the future may not specifically arise from the broken down mRNA. So does the body flush out (pardon my informality/ignorance on the right terminology) all the components of the vaccine somehow?
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Re:mRNA vaccines – a new era in vaccinology (2018) by Fomite on Wednesday April 21, 2021 @08:33PM (#26897224)
The rest of the components are also broken down. The components are lipids (fats) meant to protect the mRNA while it's being introduced, some salts for stabilization, and sucrose.

Your body knows how to handle all of those perfectly well, and yes, most of them will be excreted.

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