Also whether there are other abstractions which might help you work in a way which has different performance characteristics. For example, I've used re:dom (https://redom.js.org/) on projects in the past, LitElement/lit-html are fairly visible, and I know there are at least a couple JSX-without-vdom libraries as well.

There isn't a right answer here: it's always going to be a balance of the kind of work you do, the size and comfort zones of your team, and your user community.