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A comment on A new twist on using ‘personalized’ stem cells for studying dementia. Parent comment

Re:A new twist on using ‘personalized’ stem cells for studyi... by kick_in_the_doo on Wednesday April 14, 2021 @03:36PM (#26811972)
Do AD drugs attempt to reduce the concentration of APOE in the brain? If so, is it known if these drugs either failed to reduce the concentration of APOE, or succeeded in reducing concentration but still didn't work?
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Re:A new twist on using ‘personalized’ stem cells for studyi... by benrapscallion on Wednesday April 14, 2021 @03:41PM (#26812050)
“Reduce APOE” is an oversimplified view. The mechanisms by which the AD-associated E4 genotype (arg112, arg158) results in disease are still poorly understood. The main therapeutic hypothesis for AD is to reduce the levels of pathogenic plaques and aggregates using antibodies.
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Re:A new twist on using ‘personalized’ stem cells for studyi... by kick_in_the_doo on Wednesday April 14, 2021 @04:30PM (#26812635)
Interesting. And these studies have shown that medicine which reduces these plaques doesn't actually help with AD symptoms?
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