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Re:EU Commission to end AstraZeneca and J&J vaccine contract... by physicsguy on Wednesday April 14, 2021 @10:41AM (#26807725)
On top of that, we wouldn't even yet know if there were any long term side effects from Pfizer, etc.
Re:EU Commission to end AstraZeneca and J&J vaccine contract... by josiea on Wednesday April 14, 2021 @01:55PM (#26810635)
The publication to follow is the CDC Advisory Committee on Immunization Practices (ACIP) monthly reports. There's a report from January and one latest is from March 1.

So far no statistically significant adverse events have occured for either pfizer or moderna vaccines. I follow them closely.

Re:EU Commission to end AstraZeneca and J&J vaccine contract... by shlant on Wednesday April 14, 2021 @11:33AM (#26808507)
although we do not have data yet to show if there are any side effects 1+ years after vaccination, it would be very unlikely that there would be. Serious side effects from vaccines are almost always immediate and seen within a few weeks after administration, not months or years later.

https://www.cdc.gov/vaccinesafety/concerns/concerns-history....

Re:EU Commission to end AstraZeneca and J&J vaccine contract... by bmj on Wednesday April 14, 2021 @11:38AM (#26808580)
Except this particular vaccination mechanism (mRNA) has never been licensed for use in humans. Yes, there has been research, but never any sort of trial on the scale of what is happening right now. So, we really don't know what the long term effects of this particular type of vaccine are.

I'm not trying to cast doubt on the efficacy of the vaccines that have been approved. Rather, I'm simply pointing out we don't have much data on the long term effects on humans.

Re:EU Commission to end AstraZeneca and J&J vaccine contract... by ac29 on Wednesday April 14, 2021 @09:13PM (#26815112)
mRNA is rapidly degraded once in the body (really anywhere that isnt cold storage), existing for hours to days at most after injection. There isnt a really plausible reason why there would be no serious short term side effects reported after hundreds of millions of shots, but a hidden risk of long term serious side effects.
Re:EU Commission to end AstraZeneca and J&J vaccine contract... by shlant on Wednesday April 14, 2021 @11:46AM (#26808693)
yes you are correct that we don't really know until we know, but there is good reason to believe that mRNA vaccines are actually safer than traditional methods

https://www.hsph.harvard.edu/news/multimedia-article/were-be...

This seems to be at least partially supported by the current risks in regards to currently available non-mRNA vaccines (such as AZ).

Also I'm not really sure what saying "we don't know the long term effect are" accomplishes. It's not really adding much to the conversation.

Re:EU Commission to end AstraZeneca and J&J vaccine contract... by cm2187 on Wednesday April 14, 2021 @12:10PM (#26809088)
The conversation is about the respective merits of one vaccine over another. The fact that one is a new approach with no long term data on humans whether the other is a traditional approach is relevant.
Re:EU Commission to end AstraZeneca and J&J vaccine contract... by selectodude on Wednesday April 14, 2021 @12:23PM (#26809272)
J&J and AZ adenovirus-vector covid vaccines are highly novel vaccines that are very similar to mRNA vaccines, just with a different delivery mechanism.
Re:EU Commission to end AstraZeneca and J&J vaccine contract... by hef19898 on Wednesday April 14, 2021 @01:05PM (#26809901)
Adeno virus based vector vaccines are a pretty old idea.
Re:EU Commission to end AstraZeneca and J&J vaccine contract... by Imnimo on Wednesday April 14, 2021 @01:45PM (#26810498)
I was under the impression that adenovirus vaccines have only been been approved in the past year or two - a few for Ebola and the new ones for Covid. Are there others that have been around before that?

It doesn't seem like it really matters if adenovirus vector vaccines is an "old idea" - after all, the idea of using MRNA has also been around for a long time. But if we've only started actually using them recently, how different is our knowledge of long-term effects?

Re:EU Commission to end AstraZeneca and J&J vaccine contract... by hef19898 on Wednesday April 14, 2021 @02:19PM (#26810962)
They are tested and researched since at least 2004. Not for Covid-19 of course.
Re:EU Commission to end AstraZeneca and J&J vaccine contract... by saurik on Wednesday April 14, 2021 @11:31PM (#26815939)
And mRNA vaccines were first tested in the 90s and started getting more substantial research in 2008: the timelines seem similar?
Re:EU Commission to end AstraZeneca and J&J vaccine contract... by JamisonM on Wednesday April 14, 2021 @02:19PM (#26810960)
Your impression is correct.

The fact that it is an "old idea" is indeed unimportant, but what is very, very important is that large scale study over long periods has already been performed on that vaccination platform so we really do know a lot about it.

That means that the similarity to mRNA is a good thing in terms of any worries about unexpected consequences. Of course it also means that we know that the risk of any unexpected consequences for adenovirus vaccines is also very low.

Re:EU Commission to end AstraZeneca and J&J vaccine contract... by randomsearch on Wednesday April 14, 2021 @12:56PM (#26809785)
They’re saying “we don’t have any data on long term studies of such vaccines”, which is an important point. There is a risk there, and there’s no obvious way to manage it.
Re:EU Commission to end AstraZeneca and J&J vaccine contract... by bmj on Wednesday April 14, 2021 @12:51PM (#26809715)
Also I'm not really sure what saying "we don't know the long term effect are" accomplishes. It's not really adding much to the conversation.

You are making the claim that there may not be any long term effects to the vaccine, but the information you cite has nothing to do with mRNA-based vaccines. I'm simply suggesting we don't have the data yet to make such claims.

Re:EU Commission to end AstraZeneca and J&J vaccine contract... by shlant on Thursday April 15, 2021 @10:45AM (#26821127)
the link I posted was to provide a list of known vaccine adverse reaction events throughout history to show that none of them occurred months after vaccination. Adverse events are almost always acute so the fact that we haven't seen widespread serious side effects after 6+ months means they are very likely incredibly safe.
Re:EU Commission to end AstraZeneca and J&J vaccine contract... by shishy on Wednesday April 14, 2021 @11:40AM (#26808618)
edited because its not worth
Re:EU Commission to end AstraZeneca and J&J vaccine contract... by srswtf123 on Wednesday April 14, 2021 @12:49PM (#26809700)
By saying "I'm not trying to cast doubt" they in fact acknowledge their statement casts doubt. Surely you can see how...?
Re:EU Commission to end AstraZeneca and J&J vaccine contract... by imchillyb on Wednesday April 14, 2021 @12:47PM (#26809649)
Almost one-third of new drugs approved by the FDA ended up years later with warnings about unexpected, sometimes life-threatening side effects.

https://www.nbcnews.com/health/health-news/new-drugs-found-c...

Your supposition about likelihood bears no resemblance to reality. It's almost as if you're misleading people on purpose. I certainly hope that's not the case.

Fully 1/3 of all medications approved by the FDA turn out to have serious, and some life-threatening, side effects YEARS after the medication was approved.

______

You realize that this new 'vaccine' bears no resemblance whatsoever to any prior vaccinations?

This new Covid Vaccine is not a true vaccine. This is a drug that modifies the inner workings of cells.

That is not a vaccine but a 'new drug'.

I repeat: 1/3 of all new drugs have serious, and sometimes life threatening, reactions attributed to them between 1-5 years after the drug's approval and release to the public.

1/3...

That is not an insignificant number, and it is HIGHLY LIKELY that this new drug will have similar issues.

Re:EU Commission to end AstraZeneca and J&J vaccine contract... by zosima on Wednesday April 14, 2021 @01:12PM (#26810008)
Well, except that these serious adverse effects are often so rare to not have any way of reaching statistical significance. Especially when you consider that you're looking for associations between medication and any indication. Just by random chance you'd get a many associations between serious diseases and any medication.

The very rare and very serious side effects are tracked closely, and it's likely that for a vast number of medications, even though the very rare side effects are written on the packaging, there actually is no causal connection with the medication whatsoever.

Re:EU Commission to end AstraZeneca and J&J vaccine contract... by hef19898 on Wednesday April 14, 2021 @01:03PM (#26809881)
Every vaccine uses body cells to a certain extent. Sure, mRNA vaccines are new, but the underlying mechanism is not.

Vaccines are behaving differently from drugs. Once they took effect, and your immune system reacted, it is over. And with millions of people vaccinated by now, for months, any adverse effects would have shown. That's why we discuss blood clots, under normal circumstances these rare cases would have gone unnoticed for quite a while.

Re:EU Commission to end AstraZeneca and J&J vaccine contract... by tialaramex on Wednesday April 14, 2021 @02:12PM (#26810864)
The effect seen with these two adenovirus platform vaccines seems to be exactly what this would suggest we should expect too.

Roughly the immune system says "OK, let's attack things this shape" - which is why it's so useful for defending us against a wide variety of viruses - but alas, the shape it's picking in some patients happens to also match Platelet Factor 4, so now they are mounting an immune defence against their own blood clotting mechanism which is bad.

I don't know (perhaps if I read more papers about this I'd find out) whether it is suspected that the immune system makes this bad matching choice based on the spike protein (which we want it to match because of this coronavirus killing millions of people) or the adenovirus (which even if it could replicate in humans, which it can't, basically gives you the common cold so who cares) which is delivering it. If it's the latter, that's showing an advantage to the mRNA vaccines, since they don't need a viral delivery mechanism at all.

Re:EU Commission to end AstraZeneca and J&J vaccine contract... by peytn on Wednesday April 14, 2021 @02:08PM (#26810806)
> any adverse effects would have shown

As I understand, the required teratogenicity study in rats with Pfizer is ongoing as of two weeks ago [1]. It’s rather optimistic to claim we’ve seen everything when even animal studies haven’t completed. Vaccine science itself is rapidly developing. Now I don’t think there will be issues with this drug, but surprises may lurk still.

[1]: https://www.gov.uk/government/publications/regulatory-approv...

Re:EU Commission to end AstraZeneca and J&J vaccine contract... by tempestn on Wednesday April 14, 2021 @01:14PM (#26810047)
You can't compare vaccines to the overall universe of drugs like that. The main difference is that drugs that are intended to be taken over the long term can develop long term side effects. Vaccines are taken once or a few times, and then they're done. The parent is correct that complications arising from vaccines years after they're taken just isn't something that should be expected to happen.
Re:EU Commission to end AstraZeneca and J&J vaccine contract... by throwawayboise on Wednesday April 14, 2021 @01:56PM (#26810656)
Would your feeling change if we discover that yearly boosters of the COVID vaccine will be required indefinitely?
Re:EU Commission to end AstraZeneca and J&J vaccine contract... by tempestn on Wednesday April 14, 2021 @04:51PM (#26812894)
No, because again, you take the vaccine, it causes an immune response, and then it leaves your system. Even if you then take it again a year later. It's not like a drug that you're regularly taking, which remains in your system. What would change my mind is if I saw vaccinologists explaining a mechanism by which a vaccine could cause long-term side effects, rather than the opposite.
Re:EU Commission to end AstraZeneca and J&J vaccine contract... by mynameisvlad on Wednesday April 14, 2021 @03:30PM (#26811905)
The flu vaccine is still called a vaccine and it’s delivered yearly and while not required is highly recommended indefinitely.

Why would this be any different?

Re:EU Commission to end AstraZeneca and J&J vaccine contract... by jhayward on Wednesday April 14, 2021 @02:03PM (#26810739)
> You realize that this new 'vaccine' bears no resemblance whatsoever to any prior vaccinations?

> This new Covid Vaccine is not a true vaccine. This is a drug that modifies the inner workings of cells.

Flagged as misinformation. Complete nonsense.

Re:EU Commission to end AstraZeneca and J&J vaccine contract... by shlant on Thursday April 15, 2021 @10:33AM (#26821006)
we are not talking about new drugs in general - we are talking specifically about vaccines. Here is an opportunity to easily prove your point: show me significant examples of serious side effects from vaccines 6+ months after they were administered.

It's clear with statements like "This new Covid Vaccine is not a true vaccine" that you are just parroting anti-vax talking points. Nobody changed the definition of vaccines and mRNA vaccines fit the definition no matter how you describe them

https://sciencebasedmedicine.org/the-latest-antivax-false-cl...