I find that my Mitosis, which has tons of thumb selection, really alleviates the load on my fingers because the chords only ever involve two digits per hand at the very most.
Also I use Dvorak so my fingers move exceedingly little compared to QWERTY; when I first tried to learn to touch-type QWERTY the "right way" with leaving my hands on the home row, my wrists started hurting so I got angry and switched to Dvorak.
Using QWERTY but leaving your hands stationary is going to require your fingers to be doing a ton of reaching and increase the strain.
It's a very nice keyboard, and scratches my itch for trying out a compact, minimalist, hackable keyboard without going to something that looks like it would be utterly wrist-destroying like the Planck.
I also do find it to be more comfortable than a standard keyboard, but, given the nature of my comfort issues, I think I would find that to be the case for any split keyboard. I don't find it to be more comfortable than my more standard split keyboard, but my more standard split keyboard is a (relatively) large beast that dominates my desk.
I'm hoping that that it's just that I'm using different muscles, and I need to get used to it. But I'm also becoming increasingly prepared to face the possibility that this keyboard is harder on my hands, because it takes work away from my elbows and shoulders, and gives it to my wrists and fingers.