Yes

I get almost exactly the EPA estimate on fleet of ~25yo cars, trucks and minivans. The car is almost always on the high end. I'm supposed to get 22. I get 21.something or 22.something or 23.something from week to week with 22 being most common. The vans and the trucks I don't drive enough to have a good feel for if they're less than an mpg high or low but they are definitely within +/-1mpg.

My commute is pretty much exclusively 70-90mph highway driving with approx four pulls (stoplights) from 0 to 50/70 (traffic speed in that area, depending on conditions) and am not shy about using all of 2nd gear.

You may need to drive less in the cities (where gas engines are weakest), and be more conscious of braking and accelerating.

From what I understand, the EPA changed their measuring method many, many years ago, to include using the air conditioner, etc; and, from what I can see, mine is well within that range. In fact, I believe it regularly does better than its estimated EPA or right on it. Subaru WRX.

I only approach EPA estimates when the tank nears empty and my right foot changes its behavior dramatically due to anxiety. I don't doubt that it is possible, but I find the kind of driving it requires to be unenjoyable. I don't have a lead foot and I enjoy spending less money to travel a given number of miles, but I do not often reach the optimal MPGs.

I exceed the EPA highway MPG when using cruise control for 100s of miles w/ little traffic. When driving manually or being a bit more aggressive with passing, MPG falls below the MPG estimates.

I had to look up the EPA mpg for my car, but I routinely get over the highway mileage (most of my driving is 400mi+ highway trips)--I got about 42-ish mpg and the highway mileage is 38mpg.