A major use case I have for WSL2 requires systemd, full stop (it's critical for the package manager I use.) It's pretty painful not having it available, and this is really something that needs improvement IMO. To be fair, this could be fixed in the software too (to some extent, not fully but working) which would also be a solution. But I suspect this isn't the only problem people encounter. There's a lot people use modern Linux for.

In practice that hasn't been a roadblock for me, because VMWare Workstation 15.5 finally supports running on top of Hyper-V, so I can have both working at once. Moving everything to a single hypervisor API has some nice benefits...