Loss of myelin is one of the major factors of age-related brain deterioration

Re:Loss of myelin is one of the major factors of age-related... by sva_ on Tuesday March 16, 2021 @05:28AM (#26474592)

Increasing omega3 was a major one for me, definitely decreased chronic inflammation. The problem occurs if one's omega6:omega3 ratio is off, and most westerner's diets are very high in predominantly omega6 fatty acids[0] (such as olive oil, and most other oils). Though if you choose to supplement omega3, make sure it is controlled for mercury-contaminants.

With fat-soluble vitamins such as Vitamin D, be vary of vitamin toxicity (Hypervitaminosis[1]), as they accumulate in the body. But you'd probably have to take a huge amount over a long time to get there.

Another interesting supplement might be L-Carnitine[2], especially if you eat little/no meat.

[0] https://pubmed.ncbi.nlm.nih.gov/12442909/

[1] https://en.wikipedia.org/wiki/Hypervitaminosis

[2] https://examine.com/supplements/l-carnitine/#effect-matrix

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Re:Loss of myelin is one of the major factors of age-related... by Delk on Tuesday March 16, 2021 @11:50AM (#26478410)

How did you figure out the change decreased chronic inflammation? Was there a change in inflammatory markers or something? Or more of a hunch?

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Re:Loss of myelin is one of the major factors of age-related... by sva_ on Tuesday March 16, 2021 @03:17PM (#26481523)

I'm a bit shy to admit, but the most objective marker was a significant reduction in acne (on my shoulders). But overall I also feel a lot calmer, I digest food better, I sleep better, and some other things that are hard to pinpoint. I just have an overall greater feeling of well-being. I know this is only n=1 and hard to prove that it's due to omega3, but I just really feel like it is closely related.

I also have to point out that I've eaten a vegetarian diet since about 2008. I always thought I had a pretty healthy diet and blood work confirmed that, but it appears that it didn't control for omega3 concentrations. Part of that diet was that I consumed large amounts of (in particular) olive oil (omega6), and almost negligible amounts of omega3.

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Re:Loss of myelin is one of the major factors of age-related... by Delk on Tuesday March 16, 2021 @03:24PM (#26481616)

If you're feeling that much better overall, it's probably much healthier for you regardless of why that happens to be. Sounds like a good deal. :)

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