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A comment on Loss of myelin is one of the major factors of age-related brain deterioration. Parent comment

Re:Loss of myelin is one of the major factors of age-related... by SailingSperm on Monday March 15, 2021 @11:16PM (#26472555)
Hericium erinaceus (Lion's mane mushroom) has isolates called Hericenones and Erinacine that promote nerve growth factor synthesis and a lot of other Neurohealth benifits being found to do with the compounds the fungi produces.

The influence of Hericium erinaceus extract on myelination process in vitro https://pubmed.ncbi.nlm.nih.gov/12675022/

Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987239/

Protip: If/When buying supplements -- There's many that are just selling capsules of ground myceliated brf (brown rice flour - the substrate inoculated/grown on). Mycelium is the 'roots/pre fruiting stage' of the fungi -- The fruit body/ mushroom itself has much greater concentrations of the desired compounds.

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Re:Loss of myelin is one of the major factors of age-related... by NalNezumi on Monday March 15, 2021 @11:34PM (#26472668)
Was about to write this.

Here's also an easy summary of it's effect and recommendation If one consider buying supplements:

https://www.reddit.com/r/MushroomSupplements/comments/h090ry...

Bought some myself and tried to track its effect by playing 3DS Devilish Brain Training game and track performance.

[ Parent | on HN ]
Re:Loss of myelin is one of the major factors of age-related... by sail0rm00n on Tuesday March 16, 2021 @03:34AM (#26473960)
Did you notice an improvement?
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Re:Loss of myelin is one of the major factors of age-related... by NalNezumi on Tuesday March 16, 2021 @10:51PM (#26485951)
Nothing definitive. After 1 week I managed to achieve life-time high score in focus and short-term memory task (my previous high-score was from Uni while studying Physics), but I'm susceptible to placebo so I can't rule out that effect.

I feel like I have less "brain-fog" or rather, brain-fog induced procrastination though. But taking this coincided with a less-stressful time of my life so It might be related to both.

[ Parent | on HN ]
Re:Loss of myelin is one of the major factors of age-related... by sixdimensional on Tuesday March 16, 2021 @11:54AM (#26478462)
I tried taking this for a while, but found that I started having really bad headaches. I was taking a well known brand from Amazon. I couldn't be 100% sure the headaches were due to the Lion's mane, but felt better after I stopped taking it.

I was pretty bummed, I was hoping for a little boost from this as I had read good things about it, including the NIH articles you posted.

I can also confirm, finding the supplements that are not just mostly the ground brown rice flour is also a little difficult.

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Re:Loss of myelin is one of the major factors of age-related... by throwaway584568 on Tuesday March 16, 2021 @10:05AM (#26476814)
I have small fiber neuropathy, with de-mylinated peripheral nerves. I tried lion's mane (amongst many other things), but it didn't help.

I'd made sure t get one that was comprised only of the fruiting bodies, with a tested percentage of polysaccharides.

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Re:Loss of myelin is one of the major factors of age-related... by jonathanleane on Monday March 15, 2021 @11:43PM (#26472748)
How do you know if you're getting the actual mushroom vs. the substrate?
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Re:Loss of myelin is one of the major factors of age-related... by hanniabu on Monday March 15, 2021 @11:50PM (#26472812)
If only there was some body of regulation that could help sort this stuff out without influence from industry. (not sarcasm)
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Re:Loss of myelin is one of the major factors of age-related... by pstuart on Tuesday March 16, 2021 @12:31AM (#26473037)
Agreed, but that regulation should be on purity and label accuracy, and not venture into "sorry, we don't approve of this -- you can't have it".
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Re:Loss of myelin is one of the major factors of age-related... by SailingSperm on Tuesday March 16, 2021 @01:07AM (#26473232)
The ingredients list / packaging should say something like dried fruiting body... or if you're getting the rubbish = myceliated grain or mycelial biomass. The reddit link provided by NalNezumi is very good.

Here's just another link of some lighter details. https://learn.freshcap.com/tips/myceliated-grain/

[ Parent | on HN ]
Re:Loss of myelin is one of the major factors of age-related... by hinkley on Tuesday March 16, 2021 @12:32AM (#26473047)
Learn to cook lions main. It’s very distinct.
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Re:Loss of myelin is one of the major factors of age-related... by fsn4dN69ey on Tuesday March 16, 2021 @01:34PM (#26480071)
Are there any concerns about the active NGF compounds being 5a-reductase inhibitors?
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Re:Loss of myelin is one of the major factors of age-related... by collyw on Tuesday March 16, 2021 @04:37AM (#26474260)
They say similar things about psilocybin and magic mushrooms, but some people still eat the mycelium to get the effects. I guess it's more economical to just grow mycelium.
[ Parent | on HN ]