What about "important" emails in your inbox that you have not yet had a chance to take action on? Can you be taking action on your email 24 hours a day?
I use Vim Outliner for task management.
I automate everything.
My mail comes directly into a Debian box running postfix on the end of my ADSL line.
new-alias: Echoes the alias onto the end of /etc/aliases, then runs newaliases.
kill-alias: Use sed to remove the line that matches the alias and run newaliases.
Dead simple.
Nice thing about this system is that I can immediately tell where spammers got my email address and shut it off. Also, any email that comes in that doesn't contain a SECRETKEY gets ignored, so I don't have to worry about spammers sending to [email protected] and [email protected].
I operate on the opposite principle: there is nothing sensitive in my email account. When it arrives, it is actioned and disposed of (properly) immediately.
I am not sentimental and do not keep every email "just in case" as I do not remember 99.9% of telephone conversations I've had.