How Antidepressants Work, at Last?

Re:How Antidepressants Work, at Last? by astrange on Saturday February 20, 2021 @03:54AM (#26202750)

Trazodone actually improves sleep quality when you take it for insomnia. Oddly I looked it up and apparently there is no evidence it objectively improves start time for sleep, but it sure feels like it does.

Melatonin isn't too bad for actual sleep I think, but almost all supplements give you way too much - something like 1/3mg is enough. It does give me really bad dry eyes in the morning for some reason.

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Re:How Antidepressants Work, at Last? by randycupertino on Saturday February 20, 2021 @05:52AM (#26203221)

Trazodone knocks me out. It also makes me lethargic the following day and less productive. I would only take half the lowest available dose (cut the lowest dose in half with a pill cutter) and it still gave me greatest sleep than anything else I'd ever tried. I still take it for flights and business travel (weird hotels) but otherwise it's too much for me.

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Re:How Antidepressants Work, at Last? by doggodaddo78 on Thursday February 25, 2021 @06:27PM (#26269695)

For a number of years, Mirtazapine helped me sleep, although it reduced dreaming to nil. Interestingly, the antihistamine sedation effect of it decreases at increased doses.

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