I have to ask what the hell is wrong with them - even if considering proteins as an end all you would at least consider DNA and RNA peripherally useful to look into to figure out the process of their creation and constraints.

To go with a clumsy metaphor living wheels and axle style of locomotion cannot be plausibly grown and moved by known organic structures - it would have to use it. Knowing more what can be produced would help figure out what cannot and commonalities. The reaction doesn't make any sense even for protein folding obsessived.