I am a heroin user. I do not have a drug problem

Re:I am a heroin user. I do not have a drug problem by TheAdamAndChe on Thursday February 18, 2021 @01:25PM (#26183529)

As a physician, you should know that using opioids to experience euphoria and pleasure is drastically different from using appropriate doses to combat the effects of pain. It's the euphoria and pleasure that triggers operant conditioning and the accumulation of ΔFosB that occurs in the vast majority of addictions[1]. Only after receptor downregulation does withdrawal avoidance become a factor, but once that occurs, it doubles the strength of the operant conditioning.

Use != Misuse, but use for pleasure is a direct precursor of misuse.

[1] https://en.wikipedia.org/wiki/FOSB?wprov=sfla1

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Re:I am a heroin user. I do not have a drug problem by wittyreference on Friday February 19, 2021 @11:09AM (#26194578)

dFosB also accumulates in chronic pain and in some types of acute and inflammatory pain.

The grand-parent comment to which I am replying describes near-instant addiction in the context of an opioid prescribed for pain control.

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