Depends on your usage. The biggest problem for me is the lack of Widevine and inability to play DRM media. There are also some other things that aren't easily available such as Docker or Vagrant; I don't really use these things myself, but sometimes it's handy to be able to run them for various reasons from time to time (for example I've seen projects where the test suite assumes Docker availability, and replicating that outside of Docker for just one patch isn't really a good time investment: easier to just run Docker).