Depends on selected compressor, but yes, you can. I've definitely observed zstd-1 to be a net savings, where compression/decompression costs were offset by pushing fewer bytes through the RPC and network layers - and this was only from observing the endpoints, not even counting CPU on intermediate proxies/firewalls/etc.

I wouldn't normally expect gzip to be a net savings (it's comparatively more expensive), but depending on compression ratio achieved and what layers you're passing the bytes through, I'd definitely believe it can be in some contexts.